Killed whole-HIV vaccine; employing a well established strategy for antiviral vaccines

Killed whole-HIV vaccine; employing a well established strategy for antiviral vaccines

The development of an efficient prophylactic HIV vaccine has been one of the major challenges in infectious disease research during the last three decades. Here, we present a mini review on strategies employed for the development of HIV vaccines with an emphasis on a well-established vaccine technology, the killed whole-virus vaccine approach. Recently, we reported an evaluation of the safety a...

A Strategy for Developing an HIV Vaccine

A Shot at Dendritic Cell-Based Vaccine Strategy against HIV-1

Introduction: Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop ...

Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis.

There are currently no effective vaccines for visceral leishmaniasis, the second most deadly parasitic infection in the world. Here, we describe a novel whole-cell vaccine approach using Leishmania infantum chagasi promastigotes treated with the psoralen compound amotosalen (S-59) and low doses of UV A radiation. This treatment generates permanent, covalent DNA cross-links within parasites and ...

PERCUTANEOUS NEPHROSTOMY: A WELL ESTABLISHED AND EFFICACIOUS PROCEDURE

56 percutaneous nephrostomies were evaluated in 50 patients, with a malignant underlying factor in 32 and benign conditions in 24. The clinical indication was decompression for supravesical obstruction with or without azotemia in the majority of cases. Less common indications were management of ureteral fistula, ureteral stricture dilatation, and pelvic stone extraction. Serious complicati...